News

A new model, produced by analyzing 10 different systemic sclerosis (SSc) gene expression data sets, showed that pulmonary fibrosis (PF) in SSc is likely the result of an initial insult activating the interferon signaling pathway. Researchers believe that the uncovered processes might reflect fibrotic processes in all SSc-affected tissues. The research team, led by…

Scleroderma News correspondent Dr. Ana de Barros conducted an exclusive interview with Dr. Colin Meyer, chief medical officer and vice president of product development at Reata Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company based in Irving, Texas. The interview took place during the 4th Systemic Sclerosis World Congress held in Lisbon, Portugal,…

Scientists from the University of Florence, Italy, presented a study investigating the participation of the Endothelial-to-Mesenchymal transition (EndoMT) process in the pathogenesis of systemic sclerosis (SSc) at the 4th Systemic Sclerosis World Congress in Lisbon, Portugal, that concluded Feb. 20, 2016. SSc is a chronic connective tissue disease…

New data was recently presented regarding Actelion Pharmaceuticals’ therapies and strategies to improve clinical outcomes in patients with pulmonary arterial hypertension (PAH). The data were presented at the Actelion Satellite Symposium, titled “Improving outcome in pulmonary arterial hypertension,” which was part of the 4th Systemic Sclerosis World Congress held in…

The AMBITION trial was truly a “landmark study,” Dr. Mihaela Ianosev said in an interview with Scleroderma News Today at the 4th Systemic Sclerosis World Congress, both for daring to take clinical failure — a physician’s emphasis — as its primary endpoint, and for marking “an evolution” in clinical…

At the 4th Systemic Sclerosis World Congress, recently held in Lisbon, Portugal, an international team of researchers led by Dr. Yannick Allanore from the Department of Rheumatology A, Paris Descartes University, in France, suggested a valuable predictor of mortality in patients with systemic sclerosis (SSc). The presentation was…

Digital ulcers have a significant clinical burden in patients with systemic sclerosis. In a study presented today, Feb. 19, at the 4th Systemic Sclerosis World Congress (Feb. 18-20) in Lisbon, Portugal, an international team of researchers revealed that a medical history of digital ulcers in the past 24 weeks should trigger…

A EUSTAR study on organ manifestations in the early course of systemic sclerosis (SSc) was presented today, Feb. 19, by Dr. V.K. Jaeger at the 4th Systemic Sclerosis World Congress, now underway in Lisbon, Portugal. The presentation was titled “Incidences and Predictors of Organ Manifestations in the Early…

https://sclerodermanews.com/wp-content/uploads/videos/Sequence%2001_1.mp4             Scleroderma News Today’s exclusive interview with Professor Christopher Denton, lead investigator of two Phase 3 clinical trials assessing Bayer’s class of sGC stimulators, Adempas, in PAH and PAH-CTD patients.   The 4th Systemic Sclerosis World Congress opened on Friday with a…

A team of researchers from University College London and Actelion Pharmaceuticals showed that macitentan (Opsumit) can prevent pulmonary arterial hypertension (PAH) in a mouse model of systemic sclerosis (SSc) by preventing heart tissue remodeling and functional changes. The results were presented this week by E. Derrett-Smith at the 4th…