News

Corbus Pharmaceuticals recently completed its Phase 2 clinical study (NCT02465437) evaluating the drug Resunab (JBT-101) for the treatment of diffuse cutaneous systemic sclerosis. The company expects to report results from this study later this year. Resunab is a novel synthetic oral…

Patients with systemic sclerosis and Raynaud’s syndrome have a high risk of developing other organ complications within two years after the onset of Raynaud’s, according to a study published in the journal PLoS One. The authors reported that these complications mainly occur in the skin, gastrointestinal tract, lungs, heart, kidneys and prostate.

A recent study reported that long-term treatment with Tracleer (bosentan) can be beneficial for patients with systemic sclerosis by reducing the risk or delaying the development of pulmonary arterial hypertension (PAH). Systemic sclerosis disease progression can induce PAH and interstitial lung disease, which leads to poor prognosis. The study “Beneficial effects…

Researchers have identified risk factors of pulmonary arterial hypertension (PAH) in patients with scleroderma, showing that the risk profiles differ between patients with limited and diffuse cutaneous scleroderma. The study, “Risk factors for development of pulmonary arterial hypertension in Australian systemic sclerosis patients: results from a large…

Exposure to low temperatures and emotional stress triggers the production of norepinephrine (adrenaline), which contributes to skin fibrosis in patients with systemic sclerosis (SSc), a new study says. The study, “Mechanistic Insight Into The Norepinephrine-Induced Fibrosis In Systemic Sclerosis”, published in the journal Scientific Reports, was conducted by…

Anti-inflammatory and More: Essential Oils Essentials oils, more widely known as aromatherapy, have been around for centuries.  There’s plenty of research behind the benefits of essentials oils and aromatics. We’ve discovered some ways essential oils may help with scleroderma symptoms.     Like herbs and minerals, the FDA does not regulate essentials…

Corbus Pharmaceuticals reported new findings supporting the anti-inflammatory actions of its lead compound Resunab (JBT-101), which is currently being explored in a clinical trial for scleroderma. Data from experiments in healthy volunteers showed that Resunab prevented the infiltration of immune cells, called neutrophils, and changed blood flow in a…

Antibodies against Siglec-8 (sialic acid binding immunoglobulin like lectin 8), a protein selectively expressed on certain types of immune system cells is able to inhibit fibrosis in rodent models of scleroderma and lung fibrosis, according to data presented at the 1st International Conference on Tissue Repair, Regeneration and Fibrosis.

A new study showed that certain proteins present in the blood can serve as reliable biomarkers for the detection of diffuse cutaneous systemic sclerosis (dcSSc), as well as for the distinction of different stages of disease severity. The study, “A Proteome Derived Longitudinal Pharmacodynamic Biomarker For Diffuse Systemic Sclerosis…

Ratings of digital ulcers by rheumatologists tend to differ according to the clinician involved. But a new study reports that including clinical information, such as the presence of pain or ulcer discharge, did not improve the reliability in how rheumatologists rate digital ulcers in scleroderma patients. The findings were reported in…