Posts by: Patricia Inacio, PhD

Patricia Inacio, PhD

December 11, 2018December 11, 2018

Fat-targeting Autoantibodies Linked to Increased Risk of Blood Clots, Miscarriage in Scleroderma Patients

News

Autoantibodies against fat molecules present in the membrane of cells, called antiphospholipid antibodies, are associated with an increased risk of blood clots and miscarriage among scleroderma (SSc) patients, a ... Read more

November 29, 2018November 29, 2018

High Levels of Pro-Inflammatory CX3CL1 Linked to Lung Fibrosis in Scleroderma Patients

News

High levels of CX3CL1, a pro-inflammatory molecule, in the lung tissue and blood are linked with pulmonary dysfunction in scleroderma (SSc) patients, a study reports. The study, “Augmented concentrations of CX3CL1 ... Read more

October 18, 2018October 18, 2018

Immune Cell Tilt Toward Inflammation Seen in Aging May Fuel Scleroderma, Study Says

News

As people age they accumulate a subset of more pro-inflammatory monocytes, a type of immune cell, that may ultimately contribute to the persistent low levels of chronic inflammation seen ... Read more

September 25, 2018September 25, 2018

Cannabinoid-derived Therapies Slow Fibrosis, Block Inflammation in Scleroderma, Mouse Studies Show

News

Emerald Health’s lead cannabinoid-derived investigational therapy, EHP-101, shows promise as a possible oral treatment for scleroderma, a mouse study shows. A second cannabinoid-derivative, called VCE-004.3, also showed potential to ... Read more

September 13, 2018September 13, 2018

Autoantibodies in Scleroderma Patients Trigger Profibrotic and Proinflammatory Responses, Study Finds

News

Autoreactive antibodies, or autoantibodies, were detected in the blood of patients with scleroderma (also called systemic sclerosis, or SSc) and shown to trigger proinflammatory and pro-scarring responses when added ... Read more

August 16, 2018August 16, 2018

Silica Dust Exposure Linked to Higher Prevalence of Certain Systemic Sclerosis Manifestations, Study Shows

News

Inhalation of dust particles containing silica is linked to a higher prevalence of systemic sclerosis (SSc), namely the diffuse forms of the disease, along with muscle inflammation and lung ... Read more

August 2, 2018August 2, 2018

Light Therapy Lamp Could be ‘Game-changer’ for Healing Digital Ulcers in SSc Patients

News

Light therapy delivered locally using a lamp that emits infrared, red and ultraviolet light reduced by 83 percent the burden of digital ulcers in systemic sclerosis (SSc) patients, a ... Read more

July 19, 2018July 19, 2018

Targeting Key Driver of Fibrosis a Potential Therapeutic Strategy for Scleroderma, Mouse Study Suggests

News

A protein called BAFF, or B-cell activating factor, was found to drive skin and lung fibrosis in systemic scleroderma (SSc) by altering the balance between two subsets of immune ... Read more

July 17, 2018July 17, 2018

Six-minute Walk Test Can Predict Prognosis of Systemic Sclerosis Patients, Study Suggests

News

A lower score on the six-minute walk test (6MWT) correlates with disease severity and mortality in patients with systemic sclerosis (SSc), supporting its validity in assessing the prognosis of ... Read more

July 10, 2018July 10, 2018

KL-6 Protein Can Predict Early Lung Worsening in Systemic Sclerosis with ILD, Study Says

News

High levels of a protein called KL-6, produced by lung cells and secreted into the blood, can predict early signs of lung function worsening in patients with systemic sclerosis-related ... Read more

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