Posts by: Patricia Inacio, PhD

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People with diffuse cutaneous systemic sclerosis (dcSSc) treated with lenabasum keep improving after 21 months of treatment, results from a Phase 2 open-label extension study show. Robert Spiera, MD, from ... Read more

June 7, 2019June 7, 2019

Blocking Specific ‘Signaling Molecule’ Seen to Ease Inflammation, Scarring in Early Study

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Targeting a signaling molecule called CCL24 with a new antibody was seen to lessen inflammation and scarring (fibrosis) in a mouse model of systemic sclerosis (SSc), research shows. The ... Read more

May 3, 2019May 3, 2019

PF Combined with Emphysema Decreases Survival Rates of Systemic Sclerosis Patients, Data Analysis Shows

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Combined pulmonary fibrosis and emphysema (CPFE) impairs lung function and decreases survival rates of systemic sclerosis (SSc) patients, a retrospective analysis shows. The study “Overall mortality in combined pulmonary ... Read more

April 12, 2019April 12, 2019

Estradiol Could Be Key Therapeutic Target Against dcSSc, Study Suggests

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Men older than 50 with diffuse cutaneous systemic sclerosis (dcSSc) have higher levels of estradiol, an active form of estrogen, in their blood compared to healthy males, a study ... Read more

April 9, 2019

Blood Test May Help Identify Systemic Sclerosis Patients at Risk of Poor Outcomes, Study Suggests

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A simple routine blood test that measures the levels of immune cells called monocytes may help identify patients with fibrotic diseases, including systemic sclerosis, who are at risk for ... Read more

February 21, 2019February 21, 2019

Enzyme in Skin and Blood Vessel Cells May Offer Way of Treating Scleroderma, Study Reports

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The enzyme EZH2 is present in higher-than-normal levels in fibroblasts and endothelial cells from scleroderma patients, a study shows, and suggests blocking or inhibiting EZH2 to prevent fibrosis and ... Read more

February 12, 2019February 12, 2019

Inhibiting PU.1 Protein May Hold Promise for Treating Fibrotic Diseases, Including Systemic Sclerosis

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Inhibiting the protein PU.1 has potential as a therapy to treat multiple fibrotic diseases, including systemic sclerosis, a new study contends. The study reporting that finding, “PU.1 controls fibroblast ... Read more

January 29, 2019January 29, 2019

Rituximab May Alleviate Calcinosis Symptoms in Some Scleroderma Patients, Small Study Shows

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Treatment with rituximab may help improve the clinical symptoms of calcinosis — the formation of calcium deposits in the skin and muscle — of systemic sclerosis (SSc) patients, a small study suggests. ... Read more

December 20, 2018December 20, 2018

Rituximab Stabilizes Blood Circulation in Small Vessels in Systemic Sclerosis Patients, Study Shows

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Treatment with rituximab appears to stabilize microcirculation — blood circulation in small vessels called capillaries — in patients with long-term diffuse systemic sclerosis (SSc), a study suggests. The study, ... Read more

December 11, 2018December 11, 2018

Fat-targeting Autoantibodies Linked to Increased Risk of Blood Clots, Miscarriage in Scleroderma Patients

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Autoantibodies against fat molecules present in the membrane of cells, called antiphospholipid antibodies, are associated with an increased risk of blood clots and miscarriage among scleroderma (SSc) patients, a ... Read more

Posts by: Patricia Inacio, PhD

Patricia Inacio, PhD

Lenabasum Promotes Sustained Improvements in Systemic Sclerosis Patients, Extension Study Shows

Blocking Specific ‘Signaling Molecule’ Seen to Ease Inflammation, Scarring in Early Study

PF Combined with Emphysema Decreases Survival Rates of Systemic Sclerosis Patients, Data Analysis Shows

Estradiol Could Be Key Therapeutic Target Against dcSSc, Study Suggests

Blood Test May Help Identify Systemic Sclerosis Patients at Risk of Poor Outcomes, Study Suggests

Enzyme in Skin and Blood Vessel Cells May Offer Way of Treating Scleroderma, Study Reports

Inhibiting PU.1 Protein May Hold Promise for Treating Fibrotic Diseases, Including Systemic Sclerosis

Rituximab May Alleviate Calcinosis Symptoms in Some Scleroderma Patients, Small Study Shows

Rituximab Stabilizes Blood Circulation in Small Vessels in Systemic Sclerosis Patients, Study Shows

Fat-targeting Autoantibodies Linked to Increased Risk of Blood Clots, Miscarriage in Scleroderma Patients

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