Posts by: Patricia Inacio, PhD

Patricia Inacio, PhD

February 12, 2019February 12, 2019

Inhibiting PU.1 Protein May Hold Promise for Treating Fibrotic Diseases, Including Systemic Sclerosis

News

Inhibiting the protein PU.1 has potential as a therapy to treat multiple fibrotic diseases, including systemic sclerosis, a new study contends. The study reporting that finding, “PU.1 controls fibroblast ... Read more

January 29, 2019January 29, 2019

Rituximab May Alleviate Calcinosis Symptoms in Some Scleroderma Patients, Small Study Shows

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Treatment with rituximab may help improve the clinical symptoms of calcinosis — the formation of calcium deposits in the skin and muscle — of systemic sclerosis (SSc) patients, a small study suggests. ... Read more

December 20, 2018December 20, 2018

Rituximab Stabilizes Blood Circulation in Small Vessels in Systemic Sclerosis Patients, Study Shows

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Treatment with rituximab appears to stabilize microcirculation — blood circulation in small vessels called capillaries — in patients with long-term diffuse systemic sclerosis (SSc), a study suggests. The study, ... Read more

December 11, 2018December 11, 2018

Fat-targeting Autoantibodies Linked to Increased Risk of Blood Clots, Miscarriage in Scleroderma Patients

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Autoantibodies against fat molecules present in the membrane of cells, called antiphospholipid antibodies, are associated with an increased risk of blood clots and miscarriage among scleroderma (SSc) patients, a ... Read more

November 29, 2018November 29, 2018

High Levels of Pro-Inflammatory CX3CL1 Linked to Lung Fibrosis in Scleroderma Patients

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High levels of CX3CL1, a pro-inflammatory molecule, in the lung tissue and blood are linked with pulmonary dysfunction in scleroderma (SSc) patients, a study reports. The study, “Augmented concentrations of CX3CL1 ... Read more

October 18, 2018October 18, 2018

Immune Cell Tilt Toward Inflammation Seen in Aging May Fuel Scleroderma, Study Says

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As people age they accumulate a subset of more pro-inflammatory monocytes, a type of immune cell, that may ultimately contribute to the persistent low levels of chronic inflammation seen ... Read more

September 25, 2018September 25, 2018

Cannabinoid-derived Therapies Slow Fibrosis, Block Inflammation in Scleroderma, Mouse Studies Show

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Emerald Health’s lead cannabinoid-derived investigational therapy, EHP-101, shows promise as a possible oral treatment for scleroderma, a mouse study shows. A second cannabinoid-derivative, called VCE-004.3, also showed potential to ... Read more

September 13, 2018September 13, 2018

Autoantibodies in Scleroderma Patients Trigger Profibrotic and Proinflammatory Responses, Study Finds

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Autoreactive antibodies, or autoantibodies, were detected in the blood of patients with scleroderma (also called systemic sclerosis, or SSc) and shown to trigger proinflammatory and pro-scarring responses when added ... Read more

August 16, 2018August 16, 2018

Silica Dust Exposure Linked to Higher Prevalence of Certain Systemic Sclerosis Manifestations, Study Shows

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Inhalation of dust particles containing silica is linked to a higher prevalence of systemic sclerosis (SSc), namely the diffuse forms of the disease, along with muscle inflammation and lung ... Read more

August 2, 2018August 2, 2018

Light Therapy Lamp Could be ‘Game-changer’ for Healing Digital Ulcers in SSc Patients

News

Light therapy delivered locally using a lamp that emits infrared, red and ultraviolet light reduced by 83 percent the burden of digital ulcers in systemic sclerosis (SSc) patients, a ... Read more

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