News

Exposure to low temperatures and emotional stress triggers the production of norepinephrine (adrenaline), which contributes to skin fibrosis in patients with systemic sclerosis (SSc), a new study says. The study, “Mechanistic Insight Into The Norepinephrine-Induced Fibrosis In Systemic Sclerosis”, published in the journal Scientific Reports, was conducted by…

Anti-inflammatory and More: Essential Oils Essentials oils, more widely known as aromatherapy, have been around for centuries.  There’s plenty of research behind the benefits of essentials oils and aromatics. We’ve discovered some ways essential oils may help with scleroderma symptoms.     Like herbs and minerals, the FDA does not regulate essentials…

Corbus Pharmaceuticals reported new findings supporting the anti-inflammatory actions of its lead compound Resunab (JBT-101), which is currently being explored in a clinical trial for scleroderma. Data from experiments in healthy volunteers showed that Resunab prevented the infiltration of immune cells, called neutrophils, and changed blood flow in a…

Antibodies against Siglec-8 (sialic acid binding immunoglobulin like lectin 8), a protein selectively expressed on certain types of immune system cells is able to inhibit fibrosis in rodent models of scleroderma and lung fibrosis, according to data presented at the 1st International Conference on Tissue Repair, Regeneration and Fibrosis.

A new study showed that certain proteins present in the blood can serve as reliable biomarkers for the detection of diffuse cutaneous systemic sclerosis (dcSSc), as well as for the distinction of different stages of disease severity. The study, “A Proteome Derived Longitudinal Pharmacodynamic Biomarker For Diffuse Systemic Sclerosis…

Ratings of digital ulcers by rheumatologists tend to differ according to the clinician involved. But a new study reports that including clinical information, such as the presence of pain or ulcer discharge, did not improve the reliability in how rheumatologists rate digital ulcers in scleroderma patients. The findings were reported in…

Eosinophil count in peripheral blood may be associated with disease severity in scleroderma according to a study published in the scientific journal Springer Plus.

The European Commission (EC) and the U.S. Food and Drug Administration (FDA) have both designed Ofev (nintedanib; manufactured by Boehringer Ingelheim) an Orphan Drug (ODD) for the treatment of scleroderma, as well as the associated interstitial lung disease. A large Phase 3 trial evaluating its effectiveness in scleroderma is now recruiting…

A drug called Buspar (buspirone), which is primarily used to treat generalized anxiety disorder can improve esophageal symptoms in most scleroderma patients with esophageal involvement, according to a study published in the scientific journal Arthritis Research and Therapy.

Few scleroderma patients have antibodies directed specifically against the Ku antigen, but those who do, and have them as the only autoantibody present, are more likely to have interstitial lung disease and higher levels of a muscle degradation factor. Ku autoantibodies, as noted, are rare in people with scleroderma. The…