News

A rare condition of scleroderma, known as keloidal or nodular scleroderma, characterized by the presence of rigid and well-defined nodules and plaques that look like overgrown scars (keloids), was reported in a case study published in the journal Case Reports in Dermatology. Cases of nodular scleroderma were reported in patients…

Activating a class of nuclear receptors, called peroxisome proliferator-activated receptors (PPARs), with the drug IVA337 eased fibrosis in an animal model of systemic sclerosis, researchers reported. The study, “Pan PPAR agonist IVA337 is effective in prevention and treatment of experimental skin fibrosis,” was published in the journal…

Therapeutic plasma exchange (TPE) has the potential to treat digital ulcers and Raynaud’s symptoms in patients with scleroderma, as recently reported by Scleroderma News. Now, the researcher behind the study — Edward Harris of the Scleroderma Education Project, a research fellow at the Department of Medical Microbiology and Immunology, University of…

Cytori Therapeutics recently revealed three-year clinical follow-up data of the SCLERADEC I trial (NCT01813279), showing that the improvement provided by a single dose of its ECCS-50 in hand dysfunction associated with scleroderma can be maintained over time in patients. These results are in line with the recently published…

Cytori Therapeutics recently published two-year clinical follow-up data of its SCLERADEC-I pilot trial showing that a single administration of the company’s Cytori Cell Therapy (ECCS-50) provided sustained clinical benefits for patients with hand dysfunction linked to scleroderma. The study, “Long-term follow-up after autologous adipose-derived stromal vascular fraction injection into…

Researchers found that increased levels of Th-17 cytokines are associated with interstitial lung disease in patients with systemic sclerosis (SSc). Targeting this group of cytokines may improve lung inflammation and halt the progression of lung fibrosis. Cytokines are small secreted proteins released by the immune system. They are cell-signaling molecules…

Problems with the esophagus that result in difficulties with swallowing, or regurgitation and heartburn, typically affect “only one-third” of scleroderma patients, a study reported. But in those with these difficulties, quality of life is impacted. The study, “Esophageal Motor Abnormalities in Patients With Scleroderma: Heterogeneity, Risk Factors, and Effects on Quality of…

Samumed has recently presented promising results on investigative product SM04755, a small molecule that modulates cells’ Wnt pathway, showing the drug’s potential use as a treatment for scleroderma. Samumed, a pharmaceutical company focused on regenerative medicine and oncology applications, is encouraged by the results and expects to expand its ongoing clinical trials testing…

Corbus Pharmaceuticals’ experimental therapy Resunab (JBT-101) shows promise in a clinical trial for the treatment of diffuse cutaneous systemic sclerosis (SSc). The results come from a Phase 2 trial (NCT02465437) which evaluated the safety and effectiveness of Resunab in 27 SSc patients, compared to placebo treatment in 15 patients.

Intravenous administration of iloprost may stabilize and improve symptoms of dysfunctional cardiopulmonary and blood vessel activity in patients with systemic sclerosis, possibly halting disease progression, according to new research. The study, “Long-Term Clinical Stabilization Of Scleroderma Patients Treated With A Chronic And Intensive IV Iloprost Regimen,” was published in…