Therapeutics targeting microRNA showed signs of success in mouse models of scleroderma — particularly in skin lesions with topical applications of miR-155 antagonist, according to the results of a study titled “Targeting miR-155 to Treat Experimental Scleroderma,” published in the journal Scientific Reports. MiRNA…
A new technique called nailfold videocapillaroscopy (NVC) is a potential way of identifying systemic sclerosis patients at risk of disease progression and severity, according to a presentation titled “Sensitivity to Change of NAilfold Videocapillaparoscopy and Relationship with Disease Progression,” presented at the 4th Systemic Sclerosis World Congress recently held in Lisbon, Portugal.
Patients with systemic sclerosis (SSc) frequently develop problems in the heart’s right ventricle. A new study from the Leiden University Medical Center, in the Netherlands, found that both pulmonary fibrosis and pulmonary hypertension were independently linked to the disruption of right ventricular function. Researchers know that several mechanisms might contribute to the development of…
The organizing committee of the 4th Systemic Sclerosis World Congress recently held in Lisbon, Portugal on Feb. 18-20 recognized Inventiva, a biopharmaceutical company focused on the development of treatments for fibrosis, oncology, and orphan diseases, for its innovative approach in the development of its lead drug candidate, IVA337, a promising…
Researchers at Germany’s University of Luebeck and Charité University recently presented a study where they reported that circulating antibodies against specific chemokine (small proteins with an important role in the immune system) receptors exist in higher levels in patients with systemic sclerosis, and these antibodies correlate with disease progression and clinical…
Researchers at ChemomAb and Meir Medical Center in Tel Aviv, Israel, and the University of Florence, Italy, recently presented a study investigating the therapeutic effect of the monoclonal antibody CM-101 in animal models of systemic sclerosis (SSc) and idiopathic pulmonary fibrosis (IPF). The data was presented last week in a talk…
A research team recently proposed that injecting fat and stromal vascular fraction in the face and hands of systemic sclerosis patients can significantly improve their functional capabilities and quality of life. The results were titled “Treating Scleroderma of the face and hands with fat and stromal vascular fraction” and were presented last…
Researchers at Paris Descartes University, France, recently presented the results of a study investigating the effects of estrogen in the development of experimental dermal fibrosis and on the response of profibrotic cells to the major fibrosis cytokine-transforming growth factor (TGF)-β. The presentation, “Estrogens Inhibit the Profibrotic Effects of…
Nintedanib (OFEV) seems to inhibit the activation of fibroblasts and to exert an anti-fibrotic effect in mouse models of systemic sclerosis (SSc), according to data recently presented at the 4th Systemic Sclerosis World Congress in Lisbon, Portugal, last week. The presentation, “Effects of Nintedanib on Fibrotic and…
Inventiva, a drug discovery company focused on treatments for fibrosis, oncology, and rare diseases, discussed one of its most advanced clinical products, IVA337, a new drug candidate able to act on several components of the fibrotic process and on several organs, representing a potential therapy for systemic sclerosis. The company was at the…
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