In observance of World Scleroderma Day June 29, the Scleroderma Foundation is hosting a virtual variant of its “Stepping Out to Cure Scleroderma Walk-a-thon.” The event provides an opportunity to join in a virtual walk in memory or honor of loved ones affected by scleroderma. The World…
The ability of the investigational drug crenolanib to inhibit a signaling molecule called PDGF reduced fibrosis in the skin and heart of animal models of systemic sclerosis (SSc), according to a study by researchers at the Boston University School of Medicine. The study, “Blockade of PDGF receptors by crenolanib has therapeutic…
Registration is open for the Scleroderma Foundation‘s 2017 National Patient Education Conference, July 21-23 in the Phoenix suburb of Chandler, Arizona. The conference will focus on helping patients, family members, caregivers, and others learn about therapies, manage the disease better, cope with the emotional challenges of scleroderma, stay motivated against the…
Factors in the innate immune system, as well as those in the extracellular matrix surrounding cells, are likely involved in the development of lung fibrosis in scleroderma patients, researchers suggest after linking gene mutations to the condition. Since risk factors for scleroderma typically belong to other parts of the immune system, these…
A therapy used to prevent organ rejection in patients who have a kidney, liver, or heart transplant can help people with scleroderma-associated lung disease, a study suggests. That treatment, Cellcept (mycophenolate mofetil), slowed lung function decline, according to a comparison of the results of two clinical trials. Cellcept’s effects were…
Researchers from the Stanford University School of Medicine have identified a key element that is responsible for fibrosis of many incurable and life-threatening diseases, such as scleroderma. Their finding can help develop new specific and efficient treatments to reverse tissue fibrosis processes. The finding was reported in a study titled “…
Fibrocell Science of Exton, Pa., recently started a preclinical dose-ranging study for FCX-013, an investigational drug to treat linear scleroderma. The company expects to initiate a safety study and apply for Investigational New Drug (IND) status to the U.S. Food and Drug Administration (FDA) in late 2017. The design of…
A key milestone has been achieved in the development of Inventiva’s IVA337, an anti-fibrotic drug for treating systemic sclerosis (SSc), with the enrollment of the 100th patient in the Phase 2b FASST trial. The FASST trial (NCT02503644) has now 75% of subjects enrolled, and the company expects to complete…
Corbus Pharmaceuticals of Norwood, Mass., will commence a single Phase 3 clinical trial evaluating Anabasum (formerly known as Resunab or JBT-101) to treat diffuse cutaneous systemic sclerosis (SSc). This new study — which will support a New Drug Application (NDA) — is based on guidance provided by the U.S. Food and Drug…
Blood levels of the KL-6 and SP-D proteins may help doctors monitor the progression of interstitial lung disease (ILD) associated with systemic sclerosis (SSc), a study reports. The research, “Serum KL-6 And Surfactant Protein-D As Monitoring And Predictive Markers Of Interstitial Lung Disease In Patients With Systemic Sclerosis And…
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