The launch of a Phase 1 clinical study to test the safety of Emerald Health Pharmaceuticals’ EHP-101, a cannabidiol-based oral formulation, in healthy volunteers has been announced. EHP-101 is a potential treatment for scleroderma and multiple sclerosis. The drug was designed to enhance the effectiveness of cannabidiol,…
A study involving two patients has demonstrated the effects of botulinum toxin in improving the appearance of a facial abnormality known as scleroderma en coup de sabre, which is sometimes seen in linear scleroderma. Localized scleroderma is a form of scleroderma that affects only the skin. Linear scleroderma is…
Emerald Health’s lead cannabinoid-derived investigational therapy, EHP-101, shows promise as a possible oral treatment for scleroderma, a mouse study shows. A second cannabinoid-derivative, called VCE-004.3, also showed potential to enhance anti-inflammatory and anti-fibrotic responses in animal models of scleroderma. Both EHP-101 and VCE-004.3 are derived from cannabidiol…
More than 700 medical experts, pharmaceutical executives, patient advocates, and others are expected to converge on Washington, D.C., next month for the 2018 NORD Rare Diseases & Orphan Products Breakthrough Summit. The Oct. 15-16 event, sponsored by the National Organization for Rare Diseases (NORD), takes place at the…
The cytokines IL-1 and IL-17 seem to act together to induce fibrosis and inflammation in skin and organs in people with scleroderma (also called systemic sclerosis, or SSc), according to research done with mice and human cells. The study, “…
Evaluating changes in skin pigmentation could be useful for the management of systemic sclerosis (SSc) patients, particularly to identify those at risk of developing digital ulcers, researchers suggest. This finding was reported in the study, “Association of skin hyperpigmentation disorders with digital ulcers in systemic sclerosis:…
Autoreactive antibodies, or autoantibodies, were detected in the blood of patients with scleroderma (also called systemic sclerosis, or SSc) and shown to trigger proinflammatory and pro-scarring responses when added to skin fibroblasts from healthy subjects, researchers report. Their study, “Immune complexes containing scleroderma-specific autoantibodies induce a…
A case of acute renal crisis was reported in a patient with limited cutaneous systemic sclerosis (SSc) positive for anticentromere autoantibodies. This rare case was described in the study, “A Case of Anticentromere Antibody-positive Scleroderma Renal Crisis Requiring Dialysis” that was published in the journal…
Fibrocell Science‘s gene therapy candidate FCX-013 received fast track designation by the U.S. Food and Drug Administration as a treatment for moderate-to-severe localized scleroderma, which usually does not affect internal organs. The FDA’s latest move adds to its previously granted orphan drug and rare pediatric…
High-frequency ultrasound (HFU) of the skin can help evaluate the progression and define disease activity in patients with systemic sclerosis (SSc), researchers suggest. This noninvasive method was seen to have the potential to effectively and quantitatively measure skin thickness, representing an attractive strategy to objectively assess skin changes in patients…
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