Author Archives: Ana Pena, PhD

New Questionnaire Measures Effect of Digital Ulcers on Hand Function

Researchers have come up with a new, patient-reported questionnaire to measure the impact of digital ulcers on hand function in people with scleroderma. The questionnaire, “Hand Disability in Systemic Sclerosis-Digital Ulcers (HDISS-DU),” was developed using patient interviews and trial data. It can be useful in evaluating the…

Black Patients with Scleroderma Experience Faster Disease Progression and Higher Mortality than Whites and Asians, Study Finds

Black patients with scleroderma experience faster disease progression, higher prevalence of diffuse skin involvement, and higher mortality than Asian or white patients, a study reports. In addition, Asian patients were found to have earlier disease onset, faster disease course, and more lung involvement and pulmonary hypertension…

IL-1 Cytokines May Play Distinct Roles in Scleroderma, Study Says

Certain cytokines of the IL-1 family may play important and distinct roles in the development of systemic scleroderma (SSc), in particular IL‐1β, which may contribute to worse tissue scarring, a study suggests. The findings appeared in the report, “Analysis of serum interleukin(IL)‐1α, IL‐1β and IL‐18 in patients…

TLY012 Fares Well in Mouse Model as Potential Treatment for Scleroderma

TLY012, a lab-made equivalent of a natural protein called TRAIL, can reverse skin fibrosis in mice with scleroderma by blocking important cells involved in the underlying mechanism of skin scarring, a research study found. Targeting TRAIL pathway and this novel engineered molecule may represent a promising anti-fibrotic strategy to arrest scleroderma in…