Patients with connective tissue disease or systemic sclerosis associated with pulmonary arterial hypertension (PAH) who are positive for anti-U1 RNP antibodies have more a favorable disease prognosis than patients without these antibodies, a study published in the journal Arthritis & Rheumatology showed. Anti-U1 RNP antibodies are autoantibodies directed at nuclear proteins. They are…
The 4th Systemic Sclerosis World Congress, organized by the World Scleroderma Foundation (WSF), will run Feb. 18–20 at the Lisbon Congress Center in Lisbon, Portugal, and Scleroderma News Today will be there to cover and report on the proceedings The first three Systemic Sclerosis World Congresses — held…
New research from the University of Chicago Medical Center indicates that African-Americans with connective tissue diseases, including scleroderma, are twice as likely as Caucasians with the same medical conditions to have specific risk factors for a heart attack, stroke, or cardiovascular-related death. The study, “The Prevalence of…
Fibrocell Science, Inc., recently highlighted the latest advancements in its pipeline of products focused on autologous cell and gene therapy treatments for several conditions, including scleroderma. The company’s autologous fibroblast technology uses a patented manufacturing process that involves collecting small skin biopsies from patients, separating the tissue into its component cells, and then…
Systemic sclerosis (SSc) patients are at a substantially increased risk for the development of venous thromboembolism (VTE, obstructing blood clots), including pulmonary embolism (PE) and deep vein thrombosis (DVT), a study reported. The study, “Risk of Pulmonary Embolism and Deep Venous Thrombosis in Systemic Sclerosis: A General…
Analyzing data from a genome-wide association study (GWAS), a team led by researchers at the University of Texas McGovern Medical School at Houston showed that systemic sclerosis (SSc)-related interstitial lung disease (ILD) is not genetically linked to idiopathic interstitial pneumonia. SSc-ILD has clinical and radiological similarities to idiopathic interstitial pneumonia, and…
The efficiency of adipose-derived stromal vascular fraction (ADSVF), or cells isolated from fat tissue, to treat ischemia and skin fibrosis in the hands of systemic sclerosis (SSc) patients has been investigation in a small clinical trial. A new study reported on the 12-month follow-up of patients receiving this treatment and…
Cytori Therapeutics recently announced that its Phase 3 STAR clinical trial, evaluating the efficacy and safety of Cytori Cell Therapy in scleroderma patients with hand impairment, has treated its 20th patient to reach 25 percent of its enrollment and treatment goal. The trial is continuing on the recommendation of an independent monitoring committee that evaluated safety data obtained…
A review into Wnt pathway signaling as a potential target for systemic sclerosis treatment is optimistic regarding the current status of research and development in the field. The review, “Canonical Wnt signaling in systemic sclerosis,“ was published in the journal Laboratory Investigation by Christina Bergmann and Jörg HW Distler from the …
Because the overwhelming majority of people with the skin condition scleroderma also have gastrointestinal (GI) problems, researchers in Ontario set out to review existing literature into their potential causes to help facilitate the treatment of GI symptoms in these patients. What they found, though, was too few scientific studies into GI risk factors to adequately draw conclusions. Their…
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