News

Injecting bone marrow cells designed to produce high levels of thioredoxin 1 (Trx-1) restored skin tissue in mice with systemic sclerosis (SSc), according to Chinese researchers. Their study, “Bone Marrow-Derived Mesenchymal Stem Cells Expressing Thioredoxin 1 Attenuate Bleomycin-Induced Skin Fibrosis and Oxidative Stress in Scleroderma,” appeared in the…

Cytori Therapeutics recently completed all 48-week follow-up visits in its STAR trial evaluating adipose-derived regenerative cells (ADRCs) for the treatment of patients with scleroderma-caused hand dysfunction. A total of 88 participants were enrolled, and the last patient’s 48-week visit was conducted earlier this week, the company said in a press…

Recent data from the DeSScipher Project within the EUSTAR (European Scleroderma Trials and Research) group highlights the different perceptions on disability between patients with systemic sclerosis (SSc) and physicians, and identifies the main factors of disability perceived by SSc patients. The study, “Functional disability and its predictors in…

Results from a Phase 2 trial assessing the safety and efficacy of anabasum (formerly known as Resunab or JBT-101) shows promise in treating systemic sclerosis. That study is now being extended, and a Phase 3 trial is being planned. Anabasum, Corbus Pharmaceuticals’ lead candidate, is a synthetic oral drug that…

Systemic sclerosis (SSc) may be associated with changes in gut bacteria, according to a U.S.-Norwegian study which found that SSc patients are more prone to severe gastrointestinal tract (GIT) changes and symptoms. The study, “Systemic sclerosis is associated with specific alterations in gastrointestinal microbiota in two independent cohorts,” appeared in the…

A cell therapy based on injected genetically modified human skin cells and a pill that activates a protein has the capacity for breaking down fibrosis in localized scleroderma — at least in mice. Fibrocell and Intrexon will present preclinical data on their investigational cell therapy FCX-013 for the…

In observance of World Scleroderma Day June 29, the Scleroderma Foundation is hosting a virtual variant of its “Stepping Out to Cure Scleroderma Walk-a-thon.” The event provides an opportunity to join in a virtual walk in memory or honor of loved ones affected by scleroderma. The World…

The ability of the investigational drug crenolanib to inhibit a signaling molecule called PDGF reduced fibrosis in the skin and heart of animal models of systemic sclerosis (SSc), according to a study by researchers at the Boston University School of Medicine. The study, “Blockade of PDGF receptors by crenolanib has therapeutic…

Registration is open for the Scleroderma Foundation‘s 2017 National Patient Education Conference, July 21-23 in the Phoenix suburb of Chandler, Arizona. The conference will focus on helping patients, family members, caregivers, and others learn about therapies, manage the disease better, cope with the emotional challenges of scleroderma, stay motivated against the…

Factors in the innate immune system, as well as those in the extracellular matrix surrounding cells, are likely involved in the development of lung fibrosis in scleroderma patients, researchers suggest after linking gene mutations to the condition. Since risk factors for scleroderma typically belong to other parts of the immune system, these…