Restoring the levels of a protein known as CCN3 in the skin of people with scleroderma may improve the growth of new blood vessels and become a therapeutic target in this chronic disorder, a new study suggests. The study, “Decreased CCN3 in Systemic Sclerosis endothelial cells contributes…
The gleaming new Dutch headquarters of the European Medicines Agency (EMA), fronting Domenico Scarlattilaan in Amsterdam’s suburban Zuidas business district, finally opened for business last month — just over two years after the European Union decided to relocate the EMA to the Netherlands in the wake of Brexit.
Swallowing trouble in people with scleroderma is associated with lower quality of life and a higher incidence of depression, a study found. The study, “Oropharyngeal swallowing functions are impaired in patients with scleroderma,” was published in the journal Clinical and Experimental Rheumatology. Swallowing involves both voluntary and…
Immune players known as dendritic cells play a key role in scleroderma development in the skin and may represent a new target for effective treatments, a mouse study suggests. The study, “Regulation of skin fibrosis by RALDH1-producing dermal dendritic cells via…
Localized scleroderma affects health-related quality of life (HRQoL) in young people, causing joint and muscle pain, putting limits on physical activity, and hurting body image, a study found. Teasing from peers, unwanted questions from others, and side effects from treatment were…
Scleroderma patients who develop digital ulcers are more likely to be younger at disease onset, male, and have the diffuse type of the disease, a study has found. Digital ulcers — sores on the fingers and toes — are estimated to affect half of people with scleroderma.
Women with scleroderma take longer to perform daily living tasks, especially those that require hand strength and gripping objects, such as moving things between shelves, a new study found. These findings suggest that incorporating the Glittre Activities of Daily Living test (GA-T) in clinical evaluations may help better…
Genetic testing may allow physicians to better distinguish scleroderma from its overlap syndromes and help to predict the disease’s likely course, a study reports. The study, “Whole blood gene expression profiling distinguishes systemic sclerosis-overlap syndromes from other subsets,” was published in the Journal of the European Academy…
A large-scale DNA analysis in different tissues revealed an association between scleroderma and groups of genes driving well-known inflammation pathways. This approach helps explain the complex interplay between the diverse genes associated with scleroderma development. It also shows potential to lead to targeted and effective therapies, the investigators…
A specific variant in the STAT4 gene protects people with scleroderma against the development of interstitial lung disease (ILD), a new study in patients of European descent suggests. However, more and larger studies are needed to identify the genetic risk factors that make some people with scleroderma…
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