Selexipag (ACT-293987), under development by Actelion, may be able to help individuals affected by “Raynaud’s Phenomenon Secondary to Systemic Sclerosis” in an international phase 2 clinical trial that is currently recruiting participants. The trial, initiated in October 2014, is slated to end in April 2015…
The “STAR” pivotal trial that will test Cytori Cell Therapy as a potential treatment for impaired hand function in scleroderma patients has been granted final approval for its application for an Investigational Device Exemption (IDE). The decision, which was made by a division of the U.S.
A recruiting phase 2 clinical trial sponsored by Dinesh Khanna, MD, MS at the University of Michigan, in collaboration with Bristol-Myers Squibb and National Institute of Allergy and Infectious Diseases (NIAID), is testing the hypothesis “that subcutaneous abatacept is safe and shows evidence of efficacy…
Important to the development of any treatment for scleroderma is a clinical study investigating the pharmacodynamics and pharmacokinetics of a potential drug candidate. NexMed (USA), Inc., a subsidiary of Apricus Biosciences, Inc., is sponsoring a currently enrolling clinical trial investigating these two aspects of alprostadil in systemic sclerosis (SSc)…
A Phase 1 clinical trial recently ended that involved “A Study of the Safety and Tolerability of MEDI-551 in Scleroderma.” MedImmune LLC, sponsor of the study, last updated the results of the trial in an abstract presented through Annals of the…
As patients with scleroderma and Raynaud’s phenomenon know, cold hands can be extremely bothersome and even painful. Fredrick M. Wigley, MD, of Johns Hopkins University led a phase 3 clinical trial in 2014 that evaluated Fasudil, a Rho-kinase inhibitor, for efficacy in preventing vasoconstriction in the fingers and skin,…
“Zibotentan Better Renal Scleroderma Outcome Study (ZEBRA)” is more than a standard clinical trial for scleroderma patients. Rather, the phase 2 clinical trial is a three-part clinical trial seeking to help patients with mild, moderate, or severe kidney disease due to scleroderma. University College, London is…
“Fractional Carbon Dioxide Laser Versus UVA 1 in Treatment of Localized Scleroderma,” a clinical trial currently recruiting patients, is looking to add another possible remedy to the list for systemic sclerosis (SSc). In the trial, fractional carbon dioxide laser treatment will be compared against UVA1…
An ongoing clinical trial is evaluating RoActemra/Actemra (tocilizumab) in patients with systemic sclerosis (SSc). Sponsored by Hoffmann-La Roche, this clinical trial is in phase 3, with primary outcomes of a change in modified Rodnan skin score (mRSS) and incidence of adverse events. Currently…
Certain patients with systemic sclerosis (SSc) may be at a higher risk for malignancies based on autoantibodies present in their blood. Specifically, work presented by Dr. Cosimo Bruni at the 2014 American College of Rheumatology Annual Meeting, “An Association of Anti-PM/Scl Antibody Reactivity with Risk of Malignancy…
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