Nintedanib (OFEV) seems to inhibit the activation of fibroblasts and to exert an anti-fibrotic effect in mouse models of systemic sclerosis (SSc), according to data recently presented at the 4th Systemic Sclerosis World Congress in Lisbon, Portugal, last week. The presentation, “Effects of Nintedanib on Fibrotic and…
Inventiva, a drug discovery company focused on treatments for fibrosis, oncology, and rare diseases, discussed one of its most advanced clinical products, IVA337, a new drug candidate able to act on several components of the fibrotic process and on several organs, representing a potential therapy for systemic sclerosis. The company was at the…
At last week’s 4th Systemic Sclerosis World Congress in Lisbon, Portugal, a team of researchers presented data about the role of innate lymphoid cells in the pathogenesis of systemic sclerosis (SSc) and associated fibrosis. The presentation, by T. Wohlfahrt from the Department of Internal Medicine and Institute of Clinical Immunology at…
Scleroderma News correspondent Dr. Ana de Barros conducted an exclusive interview with Dr. Colin Meyer, chief medical officer and vice president of product development at Reata Pharmaceuticals, Inc., a clinical-stage biopharmaceutical company based in Irving, Texas. The interview took place during the 4th Systemic Sclerosis World Congress held in Lisbon, Portugal,…
New data was recently presented regarding Actelion Pharmaceuticals’ therapies and strategies to improve clinical outcomes in patients with pulmonary arterial hypertension (PAH). The data were presented at the Actelion Satellite Symposium, titled “Improving outcome in pulmonary arterial hypertension,” which was part of the 4th Systemic Sclerosis World Congress held in…
At the 4th Systemic Sclerosis World Congress, recently held in Lisbon, Portugal, an international team of researchers led by Dr. Yannick Allanore from the Department of Rheumatology A, Paris Descartes University, in France, suggested a valuable predictor of mortality in patients with systemic sclerosis (SSc). The presentation was…
Digital ulcers have a significant clinical burden in patients with systemic sclerosis. In a study presented today, Feb. 19, at the 4th Systemic Sclerosis World Congress (Feb. 18-20) in Lisbon, Portugal, an international team of researchers revealed that a medical history of digital ulcers in the past 24 weeks should trigger…
A EUSTAR study on organ manifestations in the early course of systemic sclerosis (SSc) was presented today, Feb. 19, by Dr. V.K. Jaeger at the 4th Systemic Sclerosis World Congress, now underway in Lisbon, Portugal. The presentation was titled “Incidences and Predictors of Organ Manifestations in the Early…
https://sclerodermanews.com/wp-content/uploads/videos/Sequence%2001_1.mp4 Scleroderma News Today’s exclusive interview with Professor Christopher Denton, lead investigator of two Phase 3 clinical trials assessing Bayer’s class of sGC stimulators, Adempas, in PAH and PAH-CTD patients. The 4th Systemic Sclerosis World Congress opened on Friday with a…
Fibrocell Science, Inc., recently highlighted the latest advancements in its pipeline of products focused on autologous cell and gene therapy treatments for several conditions, including scleroderma. The company’s autologous fibroblast technology uses a patented manufacturing process that involves collecting small skin biopsies from patients, separating the tissue into its component cells, and then…
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