Alice Melão, MSc,  —

Corbus Pharmaceuticals is adjusting the primary efficacy outcome of the ongoing and global RESOLVE-1 Phase 3 trial of lenabasum as a possible treatment for diffuse cutaneous systemic sclerosis (SSc). The change affects only U.S. sites involved in the study and was recommended by regulatory officials. The adjustment, a change…

The U.S. Drug Enforcement Administration (DEA) has cleared the use of the active ingredient in EHP-101, an investigational therapy for treating multiple sclerosis (MS) and systemic sclerosis (SSc), according to Emerald Health Pharmaceuticals, the therapy’s developer. After a detailed review, the regulatory agency has determined that the active pharmaceutical…

The first patient with diffuse cutaneous systemic sclerosis (SSc) has been given the investigational therapy AVID200 in an ongoing Phase 1b trial, announced the therapy’s developer Forbius. The open-label study (NCT03831438), which is currently recruiting participants, was designed to assess the safety and tolerability of AVID200, as well…

Deregulation of the microorganisms that naturally populate the skin is associated with increased inflammation and disease duration in patients with systemic sclerosis, a study shows. The study, “Microbiome dysbiosis is associated with disease duration and increased inflammatory gene expression in systemic…

People with systemic sclerosis (SSc) are at higher risk for degeneration of a main wrist nerve, a study suggests. Although for many people this condition might be asymptomatic, early detection can help prevent further deterioration and problems with hand and finger movement. The study, “Median neuropathy…

Men are at greater risk of more severe and active systemic sclerosis (SSc) than are women at early stages of the disease, a large review study shows. The study, “Gender differences in early systemic sclerosis patients: a report from the EULAR scleroderma trials and research group (EUSTAR)…

The analysis of gene profile in blood samples may help identify scleroderma patients who could benefit most from stem cell transplant, a research study suggests. The study findings were discussed at the recent 2018 ACR/ARHP Annual Meeting, in the presentation “…

“Don’t Turn a Cold Shoulder to Painful Fingers” is the new campaign launched by the Raynaud’s Association to raise awareness about the pain experienced by those affected by Raynaud’s phenomenon. The association is inviting patients to share their stories, the challenges they had to deal with by being…

Evaluating changes in skin pigmentation could be useful for the management of systemic sclerosis (SSc) patients, particularly to identify those at risk of developing digital ulcers, researchers suggest. This finding was reported in the study, “Association of skin hyperpigmentation disorders with digital ulcers in systemic sclerosis:…

A case of acute renal crisis was reported in a patient with limited cutaneous systemic sclerosis (SSc) positive for anticentromere autoantibodies. This rare case was described in the study, “A Case of Anticentromere Antibody-positive Scleroderma Renal Crisis Requiring Dialysis” that was published in the journal…