What Is Sine Sclerosis?

Sine sclerosis, which is also known as sine scleroderma or systemic sclerosis sine scleroderma (ssSSc), is an extremely rare type of scleroderma.

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Unlike “regular” scleroderma, in sine sclerosis the buildup of fibrosis occurs not on the skin but in one or more internal organs, which may also be affected by Raynaud’s phenomenon. This excess of tissue is most common around problem areas like the heart, parts of the respiratory system and the kidneys. That means that this type of scleroderma is much harder to diagnose as it’s not visible to the naked eye.

MORELearn more about limited systemic scleroderma.

Look out for signs that are centered around the organs affected, including heartburn, difficulty swallowing, shortness of breath, intestinal problem and kidney problems, among others.

While there’s currently no known treatment for the origin of the disease (the overproduction of collagen), there are several treatments that may help manage the symptoms. Any treatment plan will need to be monitored by a team of specialists.

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Scleroderma News is strictly a news and information website about the disease. It does not provide medical advicediagnosis or treatment. This content is not intended to be a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition. Never disregard professional medical advice or delay in seeking it because of something you have read on this website.


  1. Robert says:

    From the article: “Unlike “regular” scleroderma, in sine sclerosis the buildup of fibrosis occurs not on the skin but in one or more internal organs, which is due to Secondary Raynaud phenomenon”.
    Im not sure how sine scleroderma is due to “seconday Raynaud’s”? Its the first time Ive read this. Does the author have a source for this? I’m not sure that Raynaud’s causes fibrosis.

    • Tim Bossie says:

      Hi Robert! Thank you for your comment and helping us to make sure that our articles and factual. Sometimes things get past editing that should be changed. We have made the changes in the article to reflect the facts as presented in our source info.

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