Mesenchymal stem cells (MSCs) — a type of regulatory cell found in various tissues — work to reduce lung scarring in systemic sclerosis (SSc) by suppressing the growth of certain immune T-cells that carry the PD-1 receptor, according to a new study. PD-1 is an immune checkpoint protein…
Macrophages, a type of immune cell, may be mainly responsible for driving fibrosis, or scarring, in people with scleroderma, according to new research done in animal models. “These data suggest that a single cell type, macrophage, may be responsible for inducing scleroderma,” Sanja Arandjelovic, PhD, who co-led the study…
Abnormal fatty acid metabolism may play a role in the development of systemic sclerosis (SSc), according to a gene activity analysis. Researchers identified three genes involved in fatty acid metabolism that were significantly dysregulated in SSc patients. These changes correlated with markers of fat metabolism and disease complications, including…
Becoming educated and informed about scleroderma is a good first step. Here you’ll find general information about the disease, including diagnosis, symptoms, and causes.
It helps to know others have been where you are now. Here’s a collection of our columnists’ words of wisdom to help you along on your scleroderma journey.
There is no cure for scleroderma yet, but here you can find more information about current therapeutic approaches, as well as experimental treatments that are in the pipeline.
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