Cells derived from people with systemic sclerosis (SSc) had widespread DNA mutations compared with healthy cells, which may explain the higher risk of cancer in this patient population, according to a study. Changes included mutational patterns found solely in the genomes of certain cancers, as well as changes in…
The specific self-reactive antibodies (autoantibodies) of people with systemic sclerosis (SSc) overlap syndrome — a condition in which SSc patients have clinical signs and autoantibodies related to other connective tissue diseases — are tied to organ damage and SSc prognosis, according to a single-center study in China. Patients with…
The annual Cool Comedy, Hot Cuisine event, a star-studded fundraiser that benefits the Scleroderma Research Foundation (SRF), brought in more than $1.3 million for scleroderma research and educational outreach. Actor and comedian Jeff Ross, and Grammy Award-winning musician John Mayer were honored with the Bob Saget Legacy Award to…
CAL101, a therapy candidate for fibrosis (scarring) in scleroderma and related disorders, was found to be safe and well tolerated in a Phase 1 clinical trial, according to new data from the study. Developed by Calluna Pharma, CAL101 is a first-in-class antibody that targets S100A4, a protein previously…
Low levels of high-density lipoprotein (HDL), the so-called “good” cholesterol, are linked to more severe symptoms of systemic sclerosis (SSc) with interstitial lung disease (ILD), a study finds, suggesting that profiling fats in the blood could aid in planning more personalized treatments for the disease. The study, “Metabolomic…
A chest CT scan taken before a lung transplant can help predict survival after the transplant in people with systemic sclerosis (SSc), a new U.S. study suggests. Muscle mass, bone density, and the volume of the heart and blood vessels were among the “novel image features” of the pretransplant…
The Scleroderma Research Foundation (SRF) has announced the star-studded lineup for its annual Cool Comedy, Hot Cuisine fundraising event, slated to take place Oct. 29 at the Fairmont Century Plaza in Los Angeles. The event will be hosted by actor and comedian Jeff Ross, known as the “…
Activating TLR8, a viral defense mechanism involved in tissue fibrosis (scarring), primes monocytes isolated from the blood of people with systemic sclerosis (SSc) to produce excess amounts of a a molecule called IL-10 that can contribute to the abnormal growth of fibrotic tissue. The finding opens up possibilities for…
FT011, Certa Therapeutics’ oral treatment candidate for systemic sclerosis (SSc), will now be known under the generic name asengeprast. That decision was made by the World Health Organization (WHO), which is responsible for assigning International Non-Proprietary Names, or INNs, to pharmaceutical substances or active ingredients. INNs are globally…
Some types of disease-specific antibodies are more common in Black patients with scleroderma than white patients, a study shows. Differences in antibody profiles may help explain why clinical outcomes tend to differ for patients of different races, but the data suggest these variations can’t fully account for all the…
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