Lung Function in Scleroderma and Microparticles

Tiny pieces of damaged endothelial cells, aptly called “microparticles” due to their size, can be generated in patients with systemic sclerosis (SSc). These cell particulates are created from a variety of processes but are often the result of inflammation or shear stress from blood flow in narrowed arteries. Since pulmonary arterial hypertension (PAH) is a common co-morbidity in SSc patients, cell microparticles in these patients might be the result of cellular damage.

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