1. Gastrointestinal issues
People with systemic scleroderma may experience some digestive system and gastrointestinal tract irregularities that range from the mouth to the anal canal. Thickening and fibrosis (or scarring) of the tissues may happen because of an overproduction of collagen that usually occurs with scleroderma. All combined, muscles may become weakened and lead to abnormally slow movement of food (dysmotility) through the digestive process.