The U.S. Patent and Trademark Office has granted Galectin Therapeutics a new patent that extends coverage of its candidate therapy GR-MD-02 to treat systemic sclerosis and other diseases in which high levels of the inducible nitric oxide synthase (or iNOS) enzyme causes inflammation.
Many systemic sclerosis patients develop pulmonary arterial hypertension, but not all who are suspected of having PAH are referred for testing, according to rheumatologist Janet Pope. She called for more commitment to screening in an editorial in Arthritis Research & Therapy. The piece was titled “Pulmonary arterial hypertension in…
Results of a Phase 2 clinical trial (NCT02465437) evaluating the effects of Corbus Pharmaceuticals’ anabasum (formerly known as Resunab or JBT-101) support this treatment as a potential option for patients with diffuse cutaneous systemic sclerosis. The study showed that treatment with anabasum affects the activity of nearly 1,940 genes…
Twenty-three-year-old college student Erhabor Emokpae from Maryland was diagnosed with diffuse systemic scleroderma in 2013. Although the disease has changed his life, it hasn’t stopped him from doing one of the things he loves most: making music. MORE: How to live your best life with a chronic illness. According to the…
An imaging technique called nailfold videocapillaroscopy and a blood-based detection of systemic sclerosis (SSc) specific autoantibodies can provide helpful information for early diagnosis of the condition, according to two studies presented at the Annual European Congress of Rheumatology (EULAR) 2017, held June 14-17…
The U.S. Food and Drug Administration (FDA) has granted Rare Pediatric Disease Designation to FX-013, a Fibrocell gene therapy candidate to treat children with moderate to severe localized scleroderma. “Fibrocell CEO John Maslowski said in in a press release that the designation, in addition to FX-013’s Orphan Drug Designation,…
Soin Neuroscience recently submitted an orphan drug application to the U.S. Food and Drug Administration (FDA) for the company’s investigational drug TV1001SR (sodium nitrite), being developed for the treatment of scleroderma. Several completed clinical and preclinical trials have demonstrated TV1001SR enhances the growth of small arteries and promote blood flow. This…
Scientific advances have allowed researchers to develop therapies for pulmonary arterial hypertension (PAH) that have been shown to benefit patients with PAH related to systemic sclerosis (SSc). However, the median survival of these patients remains short, with a life expectancy of only four years from the time…
Long-term treatment with CellCept (mycophenolic acid) or Cytoxan (cyclophosphamide) can significantly reduce skin thickening in patients with systemic sclerosis (SSc), according to study published in the journal Arthritis Care & Research. About 90 percent of SSc patients have thickened skin — a hallmark of this disease. As such, it is commonly used…
Injecting bone marrow cells designed to produce high levels of thioredoxin 1 (Trx-1) restored skin tissue in mice with systemic sclerosis (SSc), according to Chinese researchers. Their study, “Bone Marrow-Derived Mesenchymal Stem Cells Expressing Thioredoxin 1 Attenuate Bleomycin-Induced Skin Fibrosis and Oxidative Stress in Scleroderma,” appeared in the…
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