News

An MRI-based measure called Digital Artery Volume Index, or DAVIX, may help predict the risk that people with scleroderma will develop ulcers on their fingers, a study suggests. “The potential of DAVIX to detect and predict digital ulcer disease could render it a useful stratification tool in clinical trials,”…

Treatment with FT011 led to clinically meaningful improvements in physical disability and lung function for some scleroderma patients given the experimental therapy in a Phase 2 clinical trial. Christopher Denton, MD, a professor at University College London, shared the results at the American College of Rheumatology (ACR) Convergence 2023…

The Scleroderma Research Foundation’s (SRF) annual “Cool Comedy – Hot Cuisine, A Tribute to Bob Saget” event, a recent evening of levity to raise scleroderma research funds and awareness, and to honor a longtime supporter, garnered more than $1.2 million. Some 500 people attended the luminary-laden event,…

Dosing has begun in a Phase 2 clinical trial evaluating aTyr Pharma’s efzofitimod, a first-in-class therapy for people with interstitial lung disease (ILD) associated with systemic sclerosis (SSc) — together known as SSc-ILD. Recruitment for the proof-of-concept EFZO-CONNECT study (NCT05892614), which aims to enroll up to 25…

Including intravenous immunoglobulin (IVIG) as part of routine care may help to ease muscle, skin, and digestive symptoms in people with systemic sclerosis (SSc), a Spanish study found. The experimental treatment was seen to be generally safe, with reported side effects being mostly mild or moderate. While these findings…

The U.S. Food and Drug Administration (FDA) has granted orphan drug designation to FT011, an experimental oral medication that Certa Therapeutics is developing as a treatment for systemic sclerosis. The FDA gives this designation to investigational treatments for rare diseases, those affecting fewer than 200,000 people…

Kyverna Therapeutics is launching a Phase 1/2 trial to evaluate its investigational cell therapy KYV-101 in adults with diffuse cutaneous systemic sclerosis (dcSSc). The move follows the therapy’s recent clearance of an investigational new drug (IND) application by the U.S. Food and Drug Administration (FDA). The trial, called…

Boehringer Ingelheim has joined the CONQUEST platform trial, adding a second experimental medication to the multidrug study launched by the Scleroderma Research Foundation (SRF) to speed therapy development for interstitial lung disease (ILD) associated with scleroderma (SSc). In a platform trial, a master protocol is used…

The U.S. Food and Drug Administration (FDA) has cleared Cabaletta Bio’s request to begin clinical testing of CABA-201, a cell therapy for adults with hard-to-treat systemic sclerosis (SSc). Cabaletta now plans to launch a Phase 1/2 clinical trial, enrolling SSc patients with severe skin manifestations or organ…

A prediction tool known as nomogram may be used to calculate the chance of a person with systemic sclerosis (SSc) and interstitial lung disease (ILD) developing progressive pulmonary fibrosis, or worsening lung scarring, a new study suggests. The nomogram essentially is a pictorial representation of a complex mathematical…