Monitoring the progression of subclinical heart disease with MRI scans suggested that abnormalities remain largely stable over time in people with systemic sclerosis (SSc), and such routine imaging may be of “minimal value” to most patients, a small study reported. The study, “Subclinical Systemic Sclerosis Primary Heart Involvement by…
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Elevations in two indices of body-wide inflammation are associated with greater disease activity in systemic sclerosis (SSc) patients, according to a recent study. The two inflammatory markers — called the platelet-to-lymphocyte ratio (PLR) and platelet-to-hemoglobin ratio (PHR) — were also associated with skin ulcers, and musculoskeletal and pulmonary…
Topical cannabidiol may safely improve the healing of digital ulcers and boost quality of life, while also easing pain in people with systemic sclerosis (SSc), a study in Italy suggests. Benefits were also seen in increasing the amount of sleep per night for those given the treatment. The study,…
A Phase 2a clinical trial testing the oral cannabidiol-derived medication EHP-101 in people with diffuse cutaneous systemic sclerosis can proceed to the higher dose groups, the therapy candidate’s developer Emerald Health Pharmaceuticals (EHP) announced. The study is taking place in the U.S., including Puerto Rico, as well as…
Systemic sclerosis (SSc) patients with interstitial lung disease (ILD) were more likely to have a diffuse cutaneous (dcSSc) disease type and certain cardiovascular complications than patients without ILD, according to a recent study in China. Those with the lung condition were also significantly more likely have elevated levels…
The protein ADAR1 occurs in great amounts in macrophages, a type of immune cell that appears in the early stages of systemic sclerosis (SSc), making the cells more active and stirring up a “turmoil” of inflammation, a mouse study found. Researchers also observed that mice in which the disease…
A 42-year-old man with scleroderma responded well to a second stem cell transplant after experiencing a disease relapse with lung involvement following his initial transplant, according to a recent report. Improvements in skin thickening and lung function were quickly seen, and the patient was still in remission two years…
A new study has found that defects in centromeres — specific regions of chromosomes — are evident in skin cells from people with systemic sclerosis (SSc). People with diffuse cutaneous (dcSSc) and limited cutaneous (lcSSc) forms of the disease showed specific alterations relative to healthy people, but chromosomal…
Various immune-related genes are not equally as active in people with systemic sclerosis (SSc) as they are in healthy individuals, and they may be candidate biomarkers for diagnosis, a study suggests. Researchers also found that two of these genes, called TNFSF13B and TYROBP, may tell how well people with…
Treatment with modified mesenchymal stem cells (MSCs) — which can differentiate into a variety of cell types — alleviated the signs of skin scarring, or fibrosis, in a scleroderma mouse model, a study showed. These MSCs, a type of adult stem cell that can modulate immune responses and suppress inflammation,…
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