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Elevated activity of a blood-clotting protein called Factor XIII (FXIII) in the bloodstream of adults with systemic sclerosis (SSc) is tied to the presence of Raynaud’s phenomenon, a common SSc symptom, a small study suggests. While most study participants had FXIII activity levels within the normal range, “patients with…

Caregivers of children with juvenile scleroderma cited a lack of knowledge about the rare disease within the medical community as the primary barrier to a proper diagnosis and treatment, according to a new survey study. For more than a quarter of the children, it took more than a year…

The degree of skin tightening is associated with changed levels of proteins implicated in inflammation and cell death among systemic sclerosis (SSc) patients with pulmonary involvement, a study in India reports. The study established protein correlations among SSc patients with different types of lung disease, which might contribute to…

Levels of microparticles, tiny molecule-filled sacs shed from cells, were altered in the bloodstream of adults with systemic sclerosis (SSc), a study reports. Elevated microparticles derived from blood-clotting platelets were associated with disease-related antibodies and longer disease duration. By contrast, lower levels of microparticles shed from endothelial cells that…

An analysis of genetic data from patient skin samples revealed four genes that may be involved in the development or progression of systemic sclerosis (SSc), as well as regulatory molecules that also might contribute. The scientists believe these four genes — SERPINE1, CCL2, IL6, and ISG15 — could be…

The National Scleroderma Foundation has awarded a $200,000 research grant to a University of Minnesota scientist to study how immune system responses drive the emergence of scleroderma — the cause of which remains unknown. The funding for researcher Rafael Contreras-Galindo, PhD, comes in the form of the two-year…

The clinical presentation of systemic sclerosis (SSc) differs significantly between adult and pediatric patients, according to a recent study in Turkey. Particularly, adults were more likely to have lung disease and to be at a higher risk of death than children, who were more likely to experience joint inflammation and…

Systemic sclerosis (SSc) patients with primary biliary cholangitis (PBC), a disease that causes inflammation and scarring of the liver bile ducts, have milder symptoms that rarely lead to major complications, compared to patients with SSc alone. A study with that finding also determined SSc-only patients had a higher incidence…

Elevated blood levels of the cold-inducible RNA-binding protein (CIRP) are linked with more severe interstitial lung disease (ILD) in systemic sclerosis (SSc) patients and may be a marker of disease activity, a study from Japan reports. “Our results suggest that serum [blood] CIRP levels may serve as a useful…

Having a higher level of education or being married may mean fewer symptoms of depression for people with systemic sclerosis (SSc), according to a systematic review of multiple studies. Researchers also observed that lung involvement, breathing problems, and tender joints were linked to more symptoms of depression, but…