Posts by: Jose Marques Lopes, PhD

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Measuring the lungs’ diffusing capacity for carbon monoxide (DLCO) may improve the ability of a screening algorithm to detect early-stage pulmonary arterial hypertension (PAH) in patients with systemic sclerosis ... Read more

July 10, 2019July 10, 2019

Older Males Using Opioids, With Muscle Disease, at Higher Risk for Pseudo-obstructions, Study Reports

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Being older, male, using opioids, having the diffuse cutaneous disease type, and muscle disease, increase the risk of pseudo-obstruction in people with systemic sclerosis (SSc), a study shows. The ... Read more

June 24, 2019June 24, 2019

Hyaluronidase Eased SSc Patient’s Problems with Eating, Dental Care, Report Says

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Injections of hyaluronidase, marketed as Hylenex, among other names, improved the ability to eat and reduced difficulties in opening the mouth and dental care in a woman with scleroderma, ... Read more

March 28, 2019March 28, 2019

ANCA Autoantibodies Associated with Worse Prognosis for Scleroderma Patients, Study Reports

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Scleroderma patients with ANCA autoantibodies have a higher prevalence of interstitial lung disease (ILD) and pulmonary embolism, as well as a greater mortality risk than those without these antibodies, ... Read more

February 14, 2019February 14, 2019

Arrhythmia Linked to Fibrosis in Asymptomatic Patients with Scleroderma, Study Suggests

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A device designed to continuously record heart rhythm showed that asymptomatic patients with scleroderma have significant arrhythmia, according to a pilot study. Findings also suggested that arrhythmia — irregular heart ... Read more

January 15, 2019January 15, 2019

Plant-derived Compound May Treat Skin Fibrosis in Scleroderma, Study Suggests

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Treatment with plant-derived salvianolic acid B (SAB) reduced skin fibrosis in a mouse model of scleroderma. The findings suggest that SAB may be an effective treatment for people with ... Read more

January 10, 2019January 10, 2019

Phase 2a Trial Will Evaluate GLPG1690 in Diffuse Cutaneous Scleroderma

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A Phase 2a clinical trial will test the investigational therapy GLPG1690 in patients with diffuse cutaneous scleroderma. The double-blind, placebo-controlled Phase 2a study, called NOVESA (NCT03798366), will evaluate the ... Read more

December 6, 2018December 6, 2018

TAK242 Prevents and Reverses Fibrosis in Mice, Could Be Potential Scleroderma Therapy, Study Suggests

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Inhibiting a key innate immunity protein known as TLR4 with a compound called TAK242 prevented and reversed skin and lung fibrosis (scarring) in mouse models, and eased the production ... Read more

November 15, 2018November 15, 2018

FAM111B Gene Mutations Not Associated with Scleroderma, Study Finds

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Mutations in the FAM111B gene are rare in scleroderma patients and not associated with disease development, according to new research. This finding was reported in the study, “Mutations of FAM111B gene ... Read more

August 28, 2018August 28, 2018

Combined Measurement of 2 New Serum Biomarkers May Speed Diagnosis of SSc-PAH Patients

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Patients with scleroderma and pulmonary arterial hypertension (PAH) have increased levels of two serum proteins, midkine (MDK) and follistatin-like 3 (FSTL3), according to a new study. The finding indicates ... Read more

Posts by: Jose Marques Lopes, PhD

Jose Marques Lopes, PhD

Lung Function Test May Offer Non-invasive Way to Detect Early PAH in SSc Patients

Older Males Using Opioids, With Muscle Disease, at Higher Risk for Pseudo-obstructions, Study Reports

Hyaluronidase Eased SSc Patient’s Problems with Eating, Dental Care, Report Says

ANCA Autoantibodies Associated with Worse Prognosis for Scleroderma Patients, Study Reports

Arrhythmia Linked to Fibrosis in Asymptomatic Patients with Scleroderma, Study Suggests

Plant-derived Compound May Treat Skin Fibrosis in Scleroderma, Study Suggests

Phase 2a Trial Will Evaluate GLPG1690 in Diffuse Cutaneous Scleroderma

TAK242 Prevents and Reverses Fibrosis in Mice, Could Be Potential Scleroderma Therapy, Study Suggests

FAM111B Gene Mutations Not Associated with Scleroderma, Study Finds

Combined Measurement of 2 New Serum Biomarkers May Speed Diagnosis of SSc-PAH Patients

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