Osteoporosis Medication Raloxifene May Be Effective for Scleroderma

Raloxifene, a medication used to prevent bone loss in postmenopausal women, was able to reduce fibrosis, or scarring, in cell and mouse models of systemic sclerosis (SSc). The research team noted that the patient stem cell-based model they used offers a promising way to evaluate therapeutic candidates for rare…

Organoid Treatment Lowers Inflammation, Fibrosis in Mice

Treatment with stem cells grown into a skin-like structure called an organoid reduced inflammation and fibrosis (scarring) in a mouse model of localized scleroderma, a new study found. The study, “Application of an iPSC-Derived Organoid Model for Localized Scleroderma Therapy,” was published in Advanced Science.