News

Self-reactive antibody levels linked to scleroderma progression: Study

Increasing levels of self-reactive antibodies in the bloodstream after the start of treatment are associated with the progression of systemic sclerosis (SSc), according to recent research. “We hypothesize that rising antibody [levels] during treatment may reflect ongoing immune activation, insufficient therapeutic response, or impending flare, whereas decreasing [levels] may…

Study links gut bacteria to severity of scleroderma-related ILD

The presence and severity of interstitial lung disease in people with systemic sclerosis (SSc) are associated with a specific combination of bacteria in the gut, a study suggests. “These species or their metabolic products may influence ILD [disease processes] and represent novel treatment targets,” the study’s researchers wrote. The…

New study finds sexual dysfunction is common in scleroderma

Sexual dysfunction is common among people with systemic scleroderma, but is rarely discussed between patients and their doctors, a new study shows. In the study, “Sexual dysfunction and perceptions of rheumatologist engagement on this issue in patients with systemic sclerosis,” the researchers said the reasons for…

EBV infections may affect risk of developing scleroderma: Analysis

Infection with Epstein-Barr virus (EBV), the virus that causes mononucleosis, may increase the risk of developing systemic sclerosis (SSc), according to a new analysis of genetic data. Findings also indicate that SSc is less likely to develop in people who’ve been infected with human immunodeficiency virus (HIV) or SARS-CoV-2, the…

Efzofitimod found safe, well tolerated in study of SSc-ILD

Efzofitimod was found to be generally safe and well tolerated by patients with systemic sclerosis-associated interstitial lung disease (SSc-ILD) in a proof-of-concept Phase 2 study. No treatment-related serious side effects were reported, with efzofitimod showing early signs of efficacy. In addition, the last patient visit has been completed in…

First SSc patient dosed in Phase 1 trial of CAR T-cell therapy

The first patient with systemic sclerosis (SSc) has been dosed in a Phase 1 trial of Adicet Bio’s investigational CAR T-cell therapy for autoimmune conditions, called ADI-001, the company has announced. Recruitment in the open-label trial (NCT06375993) is ongoing at one site in California. It’s expected…

National Scleroderma Foundation recognizes outstanding chapters

The National Scleroderma Foundation has recognized several individuals — leaders in advocacy, fundraising, and patient support — and regional chapters for their service in advancing scleroderma awareness and research. The 12 awards, given at the 2025 National Scleroderma Conference, held July 18-20 in St. Louis, were given for…

SRF joins capital effort to advance drug development for scleroderma

The Scleroderma Research Foundation (SRF) announced that it has joined Vie Ventures to advance research and accelerate the development of innovative therapies for scleroderma and other autoimmune diseases. The venture capital firm unites biotech investors with autoimmune disease organizations to fund the translation of scientific discoveries into…