Accurately determining functional impairment of the respiratory system of scleroderma patients is essential to helping their recovery from symptoms. It is especially important to scleroderma patients with interstitial lung disease and pulmonary arterial hypertension associated with their scleroderma, as their lung function is typically much worse than unaffected scleroderma patients.
Yuval Cohen (PhD), Chief Executive of Corbus Pharmaceuticals A new proposed treatment for scleroderma will soon be in Phase 2 clinical trials. Corbus Pharmaceuticals, based in Norwood, Massachusetts, recently received clearance from the FDA for their investigational new drug (IND),…
Richard Burt, MD, of Northwestern University is looking to harness the power of autologous, patient-derived stem cells for the treatment of systemic sclerosis. His previous work in a clinical trial with scleroderma motivated a new phase 3 clinical trial, entitled “…
Three key components of systemic sclerosis (SSc) are the subject of an ongoing clinical trial in University Hospital in Strasbourg, France. “Metabolomic Analysis of Systemic Sclerosis (SCLEROMICS)” is investigating prognosis, diagnosis, and exploratory research in SSc. Current knowledge in the field lacks a system of…
Selexipag (ACT-293987), under development by Actelion, may be able to help individuals affected by “Raynaud’s Phenomenon Secondary to Systemic Sclerosis” in an international phase 2 clinical trial that is currently recruiting participants. The trial, initiated in October 2014, is slated to end in April 2015…
A recruiting phase 2 clinical trial sponsored by Dinesh Khanna, MD, MS at the University of Michigan, in collaboration with Bristol-Myers Squibb and National Institute of Allergy and Infectious Diseases (NIAID), is testing the hypothesis “that subcutaneous abatacept is safe and shows evidence of efficacy…
Important to the development of any treatment for scleroderma is a clinical study investigating the pharmacodynamics and pharmacokinetics of a potential drug candidate. NexMed (USA), Inc., a subsidiary of Apricus Biosciences, Inc., is sponsoring a currently enrolling clinical trial investigating these two aspects of alprostadil in systemic sclerosis (SSc)…
A Phase 1 clinical trial recently ended that involved “A Study of the Safety and Tolerability of MEDI-551 in Scleroderma.” MedImmune LLC, sponsor of the study, last updated the results of the trial in an abstract presented through Annals of the…
As patients with scleroderma and Raynaud’s phenomenon know, cold hands can be extremely bothersome and even painful. Fredrick M. Wigley, MD, of Johns Hopkins University led a phase 3 clinical trial in 2014 that evaluated Fasudil, a Rho-kinase inhibitor, for efficacy in preventing vasoconstriction in the fingers and skin,…
“Zibotentan Better Renal Scleroderma Outcome Study (ZEBRA)” is more than a standard clinical trial for scleroderma patients. Rather, the phase 2 clinical trial is a three-part clinical trial seeking to help patients with mild, moderate, or severe kidney disease due to scleroderma. University College, London is…
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