In people with diffuse cutaneous systemic sclerosis (dcSSc), certain skin features, including levels of specific molecules and cells, depend on disease duration, a study finds. These features, combined with disease duration, allowed researchers to predict patients’ response to mycophenolate mofetil (MMF), an immunosuppressive therapy commonly used for dcSSc. These…
More than a third of adults with systemic sclerosis (SSc) who develop interstitial lung disease (ILD) see their condition progress, and those who reported increasing shortness of breath in the past month had a higher risk of death — even if their breathing tests have not declined — an…
Researchers in China have identified five genes — COL1A2, COL3A1, COL15A1, THY-1, and CCL19 — that may play a key role in lung complications associated with systemic sclerosis (SSc), according to a study. Using bioinformatics analyses of patient tissue samples, the team found that these genes were consistently overactive…
Galderma is launching a Phase 2 clinical trial to test nemolizumab, an antibody the company is developing to ease inflammation and scarring, known medically as fibrosis, in systemic sclerosis (SSc). Recruitment is planned to begin in North America, South America, and Europe in the second half of this…
Levels of certain types of immune cells are abnormally high in some people with systemic sclerosis (SSc), and this may be linked to serious kidney and lung complications — such as renal crisis and interstitial lung disease (ILD) — according to a study of blood cells from patients.
Adicet Bio expects adults with systemic sclerosis (SSc) soon to start enrolling in its ongoing Phase 1 clinical trial of ADI-001, an experimental CAR T-cell therapy that the company is developing for a number of autoimmune diseases. The company had expected sites to open to…
The presence of different autoantibodies specific to systemic sclerosis (SSc) can determine how the disease is likely to progress in terms of how patients feel or function, which could affect findings in placebo groups in randomized clinical trials and determinations of benefit with an experimental therapy, a study indicates.
Immunosuppressive medications may help to reduce inflammation in the heart and the overall burden of primary heart involvement that is associated with systemic sclerosis (SSc), a retrospective study suggests. Larger studies are needed to confirm these findings, its researchers stated. The study, “Immunosuppressive therapy to treat newly diagnosed…
The CCL2 gene, which codes for a signaling protein of the same name, is “a common characteristic gene” of both systemic sclerosis (SSc) and idiopathic pulmonary fibrosis (IPF), a serious complication of SSc that causes the lungs to become inflamed and scarred, according to…
Low levels of high-density lipoprotein (HDL), the so-called “good” cholesterol, are linked to more severe symptoms of systemic sclerosis (SSc) with interstitial lung disease (ILD), a study finds, suggesting that profiling fats in the blood could aid in planning more personalized treatments for the disease. The study, “Metabolomic…
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