collagen

January 15, 2019January 15, 2019

Plant-derived Compound May Treat Skin Fibrosis in Scleroderma, Study Suggests

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Treatment with plant-derived salvianolic acid B (SAB) reduced skin fibrosis in a mouse model of scleroderma. The findings suggest that SAB may be an effective treatment for people with ... Read more

January 8, 2019January 8, 2019

Researchers Target IGFBP-5 Protein in Search for Lung Fibrosis Therapies

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IGFBP-5, a protein that appears to be involved in the early stages of fibrosis, may be a potential therapy for lung fibrosis, new preclinical research done at the Medical ... Read more

December 6, 2018December 6, 2018

TAK242 Prevents and Reverses Fibrosis in Mice, Could Be Potential Scleroderma Therapy, Study Suggests

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Inhibiting a key innate immunity protein known as TLR4 with a compound called TAK242 prevented and reversed skin and lung fibrosis (scarring) in mouse models, and eased the production ... Read more

October 23, 2018October 23, 2018

CD248 Plays Central Role in Fibrosis Development in Systemic Sclerosis Patients, Study Suggests

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Targeting the CD248 molecule may be a good therapeutic option for patients with systemic sclerosis (SSc) due to the central role it seems to play in the development of ... Read more

September 25, 2018September 25, 2018

Cannabinoid-derived Therapies Slow Fibrosis, Block Inflammation in Scleroderma, Mouse Studies Show

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Emerald Health’s lead cannabinoid-derived investigational therapy, EHP-101, shows promise as a possible oral treatment for scleroderma, a mouse study shows. A second cannabinoid-derivative, called VCE-004.3, also showed potential to ... Read more

September 6, 2018September 6, 2018

FDA Grants Fast Track Status to Fibrocell’s Gene Therapy FCX-013 for Localized Scleroderma

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Fibrocell Science‘s gene therapy candidate FCX-013 received fast track designation by the U.S. Food and Drug Administration as a treatment for moderate-to-severe localized scleroderma, which usually does not affect internal ... Read more

August 21, 2018August 21, 2018

AdipoRon Treatment Reduces Clinical Features of Systemic Sclerosis in Mouse Model, Study Shows

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AdipoRon, a therapy targeting the signaling pathways that involve the protein adiponectin, was able to reduce clinical features of systemic sclerosis (SSc), including inflammation and skin fibrosis, in a mouse ... Read more

October 5, 2017

10 Parts of the Body Affected by Scleroderma

Scleroderma or systemic sclerosis (SSc) is a rare autoimmune disease whereby the body produces too much collagen. The symptoms a person can present are widespread and many different parts of ... Read more

October 5, 2017October 5, 2017

Innate Immune System and MicroRNA Play Crucial Roles in Scleroderma Development, Study Suggests

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The innate immune system and small RNA molecules known as microRNA are key factors in the development of scleroderma, according to a study based on previously published research. The ... Read more

October 3, 2017October 3, 2017

HIV Therapy Viracept May Benefit Systemic Sclerosis Patients, Mouse Study Shows

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Viracept (nelfinavir mesylate, NFV), an antiretroviral drug approved as a therapy against the human immunodeficiency virus (HIV), could be beneficial in the treatment of systemic sclerosis (SSc), a study ... Read more

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