collagen

December 6, 2018December 6, 2018

TAK242 Prevents and Reverses Fibrosis in Mice, Could Be Potential Scleroderma Therapy, Study Suggests

News

Inhibiting a key innate immunity protein known as TLR4 with a compound called TAK242 prevented and reversed skin and lung fibrosis (scarring) in mouse models, and eased the production ... Read more

October 23, 2018October 23, 2018

CD248 Plays Central Role in Fibrosis Development in Systemic Sclerosis Patients, Study Suggests

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Targeting the CD248 molecule may be a good therapeutic option for patients with systemic sclerosis (SSc) due to the central role it seems to play in the development of ... Read more

September 25, 2018September 25, 2018

Cannabinoid-derived Therapies Slow Fibrosis, Block Inflammation in Scleroderma, Mouse Studies Show

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Emerald Health’s lead cannabinoid-derived investigational therapy, EHP-101, shows promise as a possible oral treatment for scleroderma, a mouse study shows. A second cannabinoid-derivative, called VCE-004.3, also showed potential to ... Read more

September 6, 2018September 6, 2018

FDA Grants Fast Track Status to Fibrocell’s Gene Therapy FCX-013 for Localized Scleroderma

News

Fibrocell Science‘s gene therapy candidate FCX-013 received fast track designation by the U.S. Food and Drug Administration as a treatment for moderate-to-severe localized scleroderma, which usually does not affect internal ... Read more

August 21, 2018August 21, 2018

AdipoRon Treatment Reduces Clinical Features of Systemic Sclerosis in Mouse Model, Study Shows

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AdipoRon, a therapy targeting the signaling pathways that involve the protein adiponectin, was able to reduce clinical features of systemic sclerosis (SSc), including inflammation and skin fibrosis, in a mouse ... Read more

October 5, 2017

10 Parts of the Body Affected by Scleroderma

Scleroderma or systemic sclerosis (SSc) is a rare autoimmune disease whereby the body produces too much collagen. The symptoms a person can present are widespread and many different parts of ... Read more

October 5, 2017October 5, 2017

Innate Immune System and MicroRNA Play Crucial Roles in Scleroderma Development, Study Suggests

News

The innate immune system and small RNA molecules known as microRNA are key factors in the development of scleroderma, according to a study based on previously published research. The ... Read more

October 3, 2017October 3, 2017

HIV Therapy Viracept May Benefit Systemic Sclerosis Patients, Mouse Study Shows

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Viracept (nelfinavir mesylate, NFV), an antiretroviral drug approved as a therapy against the human immunodeficiency virus (HIV), could be beneficial in the treatment of systemic sclerosis (SSc), a study ... Read more

June 7, 2017

This 10-Year-Old Refuses to Let Scleroderma Get the Best of Her

Ten-year-old Grace began experiencing symptoms of scleroderma in 2015 when she and her family were living in China. Grace was having a hard time brushing her teeth as she couldn’t ... Read more

May 5, 2017

How Scleroderma Can Affect Your Lungs

Scleroderma is an autoimmune disease that occurs when the body overproduces collagen. This collagen can appear in any of the body’s organs, including the lungs. MORE: Six warning signs you may ... Read more

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