News

Autotaxin Protein Can Be Targeted in SSc Therapy

A group from Massachusetts General Hospital is placing possible blame for systemic sclerosis (SSc) pathogenesis on autotaxin (ATX), an enzyme involved in the production of the lipid signaling molecule lysophophatidic acid (LPA). Dr. Falvia V. Castelino, a researcher in the Rheumatology Department, presented the group’s work, “…

Probiotics Investigated in SSc Patients with GI Symptoms

Federal University of São Paulo recently initiated a phase 3 clinical trial evaluating the use of probiotics in patients with systemic sclerosis (SSc) to determine the efficacy and safety of treating gastrointestinal symptoms of SSc. As an autoimmune disease, SSc may benefit from probiotics due to their ability to…

Routine Exam for SSc Patients May Also Monitor Lung Function

Closely examining the capillaries of the fingers, perhaps one of the most non-invasive procedures possible, may be provide insight into pulmonary function in patients with systemic sclerosis (SSc). A research group from Spain, led by Drs. Ivan Castellvi and Jordi Casademont, identified worse forced vital capacity (FVC) and diffusing capacity…

Study Urges New Standards For Systemic Sclerosis Lung Transplants

New research presented at the American College of Rheumatology Annual Meeting in Boston highlights that patients with systemic sclerosis with end-stage lung disease cannot be denied lung transplantation on the premises that other extra-pulmonary factors will determine their long-term survival. Scleroderma, also known as systemic sclerosis (SSc), is an autoimmune disease…

PH Therapy Riociguat to Be Tested on Patients with dcSSc

Those in the Scleroderma community are taking note of recent news that Bayer HealthCare will be initiating a randomized, double-blind, placebo-controlled, Phase II clinical study to investigate efficacy and safety of riociguat in patients suffering from diffuse cutaneous systemic sclerosis (dcSSc), according to an announcement by the company. The study is…