Lung Function in Scleroderma and Microparticles

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Tiny pieces of damaged endothelial cells, aptly called “microparticles” due to their size, can be generated in patients with systemic sclerosis (SSc). These cell particulates are created from a variety of processes but are often the result of inflammation or shear stress from blood flow in narrowed arteries. Since pulmonary arterial hypertension (PAH) is a common co-morbidity in SSc patients, cell microparticles in these patients might be the result of cellular damage.
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